The genetics of nephrolithiasis.

Assessment of the diagnostic capability of ultrasound in early diagnosis of nephrolithiasis: a feasibility study

Relationship between urinary reflux and nephrolithiasis in children- a cross-sectional study

Aim: Urinary reflux is a probable reason of nephrolithiasis among children. This study aimed to assess the relationship between urinary reflux and other reason of stone formation in children.Methods: This cross-sectional study was carried out with 199 children diagnosed with nephrolithiasis using ultrasonography. They were hospitalized in a referral children hospital in an urban area of in Iran...

When to suspect a genetic disorder in a patient with renal stones, and why.

Nephrolithiasis is a common disorder, with a rising prevalence in the general population. Its pathogenesis is still unclear, but a role for genetics has long been recognized, especially in cases of the more common calcium nephrolithiasis. Although relatively rare, monogenic causes of hypercalciuria and nephrolithiasis do exist and their timely recognition is important from a prognostic and ther...

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients GENETICS OF URIC ACID REGULATION

Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an ageand sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4....

Metabolic and Anatomic Abnormalities Associated with Pediatric Nephrolithiasis: a Cross-Sectional Study

Background Pediatric nephrolithiasis is a condition the prevalence of which varies geographically with multiple etiologies. The aim of this study was to determine possible concomitant anatomic and metabolic disturbances in children with nephrolithiasis and to answer the questions regarding the role of each metabolic and anatomic abnormality. Materials and Methods Between 2007 and 2015, 1,080 pa...